ELI5: Explain Like I'm 5

Anti-exhaustion hypothesis

So, you know how when you run around a lot and play and have fun, you get really tired and maybe even have to rest for a little while? That's because your body gets exhausted from using up all of your energy.

But, there's this idea called the "anti-exhaustion hypothesis" that says that sometimes when you do a lot of physical activity, you actually get more energy instead of getting tired. It's like your body has a magic power that helps it keep going even when it's using up a lot of energy.

Scientists have studied this idea a lot and they think that it might be because when you exercise, your body makes more of these things called mitochondria. Mitochondria are like little power plants inside your cells that help make energy for your body to use. The more mitochondria you have, the more energy your body can make.

So, when you exercise a lot, your body makes more mitochondria and gets better at making energy. That means you might feel more energetic and less tired, even though you're doing a lot of physical activity.

It's kind of like how when you practice doing something, you get better at it over time. When you exercise and make more mitochondria, your body gets better at making energy and you might feel less tired and more energetic.
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