ELI5: Explain Like I'm 5

Antibody-drug conjugate

Okay kiddo, so let's talk about antibody-drug conjugates (ADCs)! Imagine your body is like a castle and it has guards called antibodies that keep it safe from bad germs and toxins outside. Sometimes, these bad things sneak inside the castle and the antibodies can't catch all of them because they're too sneaky. That's where ADCs come in handy!

ADCs are like special weapons that combine the power of antibodies and drugs. The scientists first create an antibody that can recognize the bad thing that's trying to harm the castle, like a harmful cancer cell. Then, they attach a tiny amount of medicine to the antibody, kind of like putting a canon on top of it!

When the ADC is injected into the body, it travels through the bloodstream and eventually finds the bad thing that matches the antibody. The antibody attaches to the bad thing like a lock and key and pulls the medicine right to it, like a bomb exploding on the enemy's castle walls!

The medicine then attacks the bad thing, killing it off and helping the antibodies to get rid of it from the castle. Because the medication is specifically targeted to only attack the bad thing, it doesn't harm any good cells in the castle, just like how a guard dog wouldn't bite his own family.

So, ADCs are like superhero weapons that use antibodies to target bad things and the power of drugs to kill them off without hurting any good cells. That's how they help keep our bodies safe from harmful invaders!