Your body normally knows how to protect you from things that might make you sick, like germs and germy things. But sometimes, your body gets confused and thinks that parts of your own body are the germy things that need to be attacked. This is called an autoimmune disease.
It's like if you had a toy that you really liked, but then it got broken and you thought it was a bad toy that needed to be thrown away. But really, it was just a mistake - you just didn't understand that the toy was actually still good and worth keeping.
Sometimes, when a person has an autoimmune disease, it can make them feel really bad and have a lot of trouble doing things they used to be able to do. The doctor will try to help by giving you special medicine or maybe changing the way you eat. This can make your body feel better and start to understand that it should be protecting you and not attacking itself.