ELI5: Explain Like I'm 5

Bailey peptide synthesis

Bailey peptide synthesis is like baking cookies, but with tiny ingredients called amino acids instead of flour and sugar.

First, we need to decide what kind of cookie we want to bake. In the same way, we need to decide what kind of peptide we want to make.

Next, we take our amino acids, which are like different colored sprinkles, and arrange them in the order we want. The order of amino acids determines what kind of peptide we will make, just like the order of sprinkles determines what our cookie will look like.

We then mix all of our amino acids together, adding a special kind of glue called a coupling reagent. This is like adding a special kind of flour and butter to our sprinkle mixture to help everything stick together.

Now we wait for our cookie to bake in the oven. In peptide synthesis, we heat everything up to make sure our amino acids stick together and form a long chain, kind of like a Christmas garland made out of sprinkles.

Finally, we take our newly formed peptide and cut off any extra bits or mistakes, just like we would cut off burnt edges or broken pieces from our cookies.

And there we have it – our Bailey peptide synthesis is complete and we have a freshly baked peptide ready for use in scientific research or medical applications!