Okay kiddo, so imagine we are trying to read a really, really big book with a lot of words in it.
Sometimes, it can be hard to read some of the words because they might be spelled differently in different places. This can be like trying to read a foreign language, where the words look different than what we're used to seeing.
Scientists who study DNA, the stuff that makes us who we are, also read a lot of big books. But instead of letters, they have a code made up of four different chemical "letters" called bases.
And just like with letters in a book, sometimes the bases can be different for the same gene or piece of DNA, making it hard to compare between people or organisms.
To make it easier to understand, a group of scientists got together and made a special "book" that they called the Cambridge Reference Sequence.
This special book has a list of all the letters that scientists should use when they're comparing DNA between different people, so they can all use the same "words" and make sure they're all talking about the same thing.
So think of the Cambridge Reference Sequence like a special dictionary for scientists who study DNA. It helps them all speak the same language when they're talking about how our genes work.