ELI5: Explain Like I'm 5

Conserved non-coding sequence

A conserved non-coding sequence is like a secret code in our DNA that doesn't tell our body how to make a protein, but still plays an important role in making sure our body functions properly. Think of it like a lock on a door - even though it doesn't open the door, it keeps things safe and secure inside.

Scientists noticed that some parts of our DNA don't change much over time, even though other parts change a lot. These parts are called "conserved," because they're always pretty much the same no matter what. And even though these parts don't tell our body how to create a protein, they can help control when and where other genes get turned on or off.

It's like they're the bossy big sibling who isn't doing any work themselves, but are telling their younger siblings what to do. They may not be making the toys, but they're making sure the right toys get to the right places at the right time.

Without conserved non-coding sequences, our body may not work properly or may not develop properly, just like a toy would be broken without the right instructions.