Imagine you have two different types of Lego blocks. One type is blue and the other type is red. When you put the red and blue blocks together, they create a barrier between them called a depletion region. It's like a fence that separates the red and blue blocks.
In a similar way, a depletion region forms when two different types of materials come together in electronics. These materials can be things like silicon or germanium. One material has extra electrons (the blue blocks) and the other has too few electrons (the red blocks). When they are put together, the extra electrons from one material fill in the spaces where there are too few electrons in the other material. This creates a depletion region between the two materials where there are no extra electrons or spaces for electrons to move.
The depletion region can affect the way electricity flows through the materials and can be used to make things like diodes (a type of electronic component). It's like a border between two countries - it controls what can go from one side to the other.