ELI5: Explain Like I'm 5

Differential adhesion hypothesis

The differential adhesion hypothesis is like playing with magnets. You know how magnets stick to each other, right? Well, cells in our body stick to each other too, but it's a little more complicated than just magnets.

Imagine you have two types of cells, like red cells and blue cells. When they touch each other, the red cells might stick together really well, but the blue cells might not stick very well to either the red cells or the other blue cells. This is because different types of cells have different amounts of stickiness to each other.

This stickiness is caused by molecules on the surface of the cells called adhesive molecules. These molecules can either attract or repel other cells, sort of like the way magnets stick together or push apart.

When cells divide or move around in our body, they can sometimes sort themselves out so that all the red cells stick together in one place, and all the blue cells stick together in another place. This is because of the differential adhesion hypothesis - since the red cells were more sticky to each other than the blue cells, they tended to stick together more and formed a clump.

This hypothesis helps explain how different types of cells can organize themselves in our bodies and form tissues and organs. It's like a big puzzle, where all the cells fit together in just the right way to make our bodies work properly.
Related topics others have asked about: