Imagine you have a big box filled with a lot of small balls. Each ball can move around in the box and bump into other balls. But imagine now that some of the balls are missing, leaving empty spaces in the box. If you look at the box from far away, you might not notice the missing balls and think that the box is still filled with balls.
This is kind of what happens in an empty lattice approximation. Scientists use this concept to study how particles, like atoms or molecules, interact with each other in a solid material. They imagine the solid material as a box made up of tiny repeating units called lattices. Each lattice can hold one particle, but in an empty lattice approximation, some of the lattices are empty, so they don't have particles in them.
Scientists use this approximation to simplify their calculations and make predictions about how the particles in the solid material will behave. Just like you can imagine the box filled with balls, even though some are missing, scientists can imagine the solid material filled with particles, even though some lattices are empty.
Of course, in real life, solids aren't completely empty, and particles interact in more complex ways than just bouncing off each other in a box. But the empty lattice approximation helps scientists make predictions and understand some of the basic properties of materials.