Okay kiddo, so imagine you are playing with your friends in your neighborhood, but there is another neighborhood across town that you never visit or play with. This neighborhood is like a genetic isolate.
Just like how you and your friends share similarities because you live in the same neighborhood and play together, people living in a genetic isolate share similarities in their genetic makeup because they live in the same area and marry within their own community.
This helps to keep certain genetic traits within the community and can create unique genetic characteristics in that group. However, it can also limit genetic diversity and increase the chances of inherited diseases because there is less mixing of genes from different communities.
Does that make sense, little one?