Genotype–phenotype distinction is a way of talking about how a living thing's DNA can affect how it looks and behaves. Genes are the instructions inside a living thing's DNA, and a genotype is the set of instructions for all of a living thing's genes. Phenotype is how all of those instructions affect what a living thing looks like and how it behaves. So, the genotype–phenotype distinction is a way of talking about how the instructions inside DNA affect what a living thing looks like and how it behaves.