Haldane's Rule is a scientific rule in biology that is used to help explain why certain species cannot breed together to make babies, even when they look similar. It comes from the scientist J.B.S. Haldane, who came up with the idea.
The rule says that male and female animals who look very similar can't have any babies together if one of them has a different number of chromosomes than the other one.Chromosomes are tiny pieces of DNA that carry information that tells our bodies how to work.
In other words, animals with different numbers of chromosomes usually can't have babies together. To make babies they need to have the same number of chromosomes. This means that even if two animals look the same, if they have different numbers of chromosomes, they still can't make babies.