ELI5: Explain Like I'm 5

History of immunology

Immunology is the study of our body's defense system that protects us from getting sick or injured. It's like having soldiers inside our body who are always ready to fight against enemies such as germs and viruses that can harm us.

Long, long time ago, people didn't know how this defense system worked. They didn't even know what a germ was or what caused them to get sick. But, as time went by, humans became smarter and more curious. They noticed that some people were getting sick while others were not. Some people even recovered from sickness without any treatment. So, they started to investigate why this was happening.

One of the earliest known examples of immunology dates back to the Chinese civilization as early as the 15th century. During battles, some people were able to survive smallpox and never got sick again. To make use of this immunity, they started a practice called variolation, which involved taking pus from the sores of someone with mild smallpox, grinding it up, and inserting it into the nostrils of another person with the hope of creating immunity.

Fast forward to the 18th century, a scientist named Edward Jenner discovered that milkmaids who had already contracted cowpox never got infected with smallpox. So, he used cowpox as a vaccine to prevent smallpox. This was the first time that the word "vaccine" was used, and it came from the Latin word for cow, "vacca".

In the late 19th century, Louis Pasteur, who is known for pasteurization, developed the first rabies vaccine. He also developed vaccines for anthrax and cholera.

In the 20th century, immunology was revolutionized by the discovery of antibiotics that could kill bacteria. This led to the development of many treatments for bacterial infections caused by germs.

The discovery of the structure of DNA in the 1950s and 1960s led to better understanding of the immune system at a molecular level. This understanding has led to the development of new treatments for diseases such as cancer, autoimmune diseases, and allergies.

In a nutshell, the history of immunology is the story of how humans have learned to understand the immune system and develop vaccines and treatments to help our bodies fight against harmful agents.