ELI5: Explain Like I'm 5

Host–guest chemistry

Okay, so imagine you are having a big party at your house, and you have invited all your friends over. You are the host of the party!

Now, usually when guests come to a party, they bring things with them - maybe snacks, drinks, or gifts. These things are like the "guest" part of host-guest chemistry.

In chemistry, a host is usually a molecule or material that has some empty space inside it, where other molecules or ions can fit inside like guests at a party. This space is called a "pocket" or "cavity." The guests that fit inside are usually smaller molecules or ions that can be held in place by the host's chemical bonds.

Just like at a party, some guests fit better with certain hosts than others. For example, a host molecule with a big pocket might be able to hold a larger guest molecule than a host with a small pocket.

Sometimes hosts can also change their shape to better accommodate guests. This is like rearranging the furniture in your house to make more space for your friends at your party.

Host-guest chemistry is important in many areas of chemistry, including drug design, materials science, and catalysis. It helps chemists understand how molecules can interact with each other and how chemical processes work.