ELI5: Explain Like I'm 5

Hypoxanthine-guanine phosphoribosyltransferase

Okay kiddo, have you ever played with LEGOs? Hypoxanthine-guanine phosphoribosyltransferase, or HPRT for short, is like a big LEGO that helps put together other things in our body.

Let's break it down. Hypoxanthine (hi-pok-san-theen) and guanine (gwa-neen) are two types of building blocks, like the different colored LEGOs you might have. Phosphoribosyltransferase (foss-for-i-bos-il-trans-fur-ace) means it's a special tool that helps stick these building blocks together.

Now, imagine you have a big bucket of LEGOs in front of you and you want to build a spaceship. You need to pick out the right colors and shapes to make it look cool. That's kind of what HPRT does, except it's not building space ships - it's building important molecules in our body.

One of the things HPRT helps make is something called purines (pyoo-rines), which are like the fuel that powers our cells. Without HPRT, our body wouldn't be able to make purines and we might not feel very good.

But there's one more important thing you need to know about HPRT - it's what we call a "housekeeping gene". You know how you have to clean up your toys and put them away when you're done playing with them? HPRT does something similar - it helps get rid of the "trash" in our cells so they stay healthy.

So even though HPRT might be a big, tricky word to say, just remember that it's like a LEGO that helps build important molecules and keeps our cells clean.