Interference is like when you're talking to someone on the phone and there's a lot of noise in the background. It's hard to hear what the person is saying because other sounds are getting in the way.
The same thing can happen with radios and TVs. When you listen to the radio or watch TV, you are picking up signals from a faraway station. But sometimes another signal from a nearby station can get in the way and make it hard to hear or see what you want.
Think of it like when you are trying to read a book, but someone else is talking loudly nearby. Their voice makes it hard for you to concentrate on what you're reading. That's interference.
To fix interference, you need to try to block out the unwanted sounds or signals. For example, you could move to a quieter place or put on noise-canceling headphones. With radios and TVs, engineers try to make sure that the station's signal is strong enough to overcome interference, but sometimes it's just too much to handle.