ELI5: Explain Like I'm 5

Molecular mimicry

Okay, kiddo, imagine you're at a costume party and everyone is dressed up in different outfits. Some people might be dressed up as superheroes, others might be dressed up as animals or even different people.

Now, imagine that there are some bad guys at the party who are trying to trick the good guys into thinking they are one of them. The bad guys might dress up in costumes that look just like the good guys' costumes to try to blend in and avoid being caught.

Well, in your body, there are also some bad guys called pathogens, which are like germs or viruses. They can cause sickness and diseases. Sometimes these pathogens try to sneak into your body by pretending to be something that your body likes or is familiar with.

This is where molecular mimicry comes in. Some of these bad guys have proteins on their surface that look very similar to the proteins your own body uses. It's like they're dressing up in the same costume as your own body's proteins.

When your immune system sees these bad guys, it might mistake them for your own body's proteins and not attack them. This is a problem because it allows the bad guys to enter your body and cause harm.

So, scientists are studying these bad guys and trying to figure out how they are tricking the immune system. They hope to find ways to help the immune system recognize these bad guys and destroy them, preventing sickness and disease.

Does that make sense, champ?