Mutagenesis is kind of like playing a game of telephone with your cells. You know how when you play telephone, you whisper a message to your friend, who whispers it to the next person, and so on, until the message gets to the end of the line? Sometimes, the message gets mixed up and isn't quite the same when it gets to the end as it was at the beginning. That's kind of what happens with mutagenesis.
Inside your cells, there's something called DNA, which is like a set of instructions that tells your cells how to do their job. Sometimes, things can come along and mess up those instructions so that they aren't quite the same anymore. These things are called mutagens.
Mutagens can be things like chemicals, radiation, or even mistakes that happen when your cells copy their DNA. When a mutagen comes along and messes up some of the instructions in your cells' DNA, that's called mutagenesis.
This can be bad news because sometimes, when the instructions are messed up, your cells won't be able to do their job correctly. For example, if a mutagen messes up the instructions that tell your cells how to make insulin, you might end up with diabetes.
Scientists study mutagenesis because it can help them figure out how mutations happen and what might cause them. They can use this knowledge to try to prevent mutations from happening in the first place or to find better ways to treat diseases that are caused by mutations.