The Pólya Conjecture is like a really cool puzzle. So, think of a puzzle that has a bunch of different shapes and colors that fit together perfectly. The shapes and colors are actually patterns called "polyominoes" (poly-oh-me-nos). These patterns can be put together to make lots of different shapes, like pictures of animals or even letters of the alphabet!
Now, the Pólya Conjecture is kind of like a rule for these polyominoes. It says that if you take any polyomino and rotate it or flip it over, it will still be the same polyomino. It's a bit like looking in the mirror and seeing yourself - even though your reflection is facing the opposite way, it's still you!
Scientists have been trying to prove the Pólya Conjecture for a really long time, because if it's true, it could help us solve lots of other puzzles and problems. But even though they've tried really hard, they haven't been able to prove it yet. Some people think it might be true, while others think it might not be true.
So, to sum it up: the Pólya Conjecture is like a puzzle that involves patterns called polyominoes, and it says that you can flip or rotate the patterns and they'll still be the same. Scientists are still working to figure out if the rule is always true.