ELI5: Explain Like I'm 5

Polypurine Reverse-Hoogsteen hairpins

Okay, kiddo, so you know that our bodies are made up of tiny parts called cells, right? And inside those cells, we have something called DNA, which is like a set of instructions for how our bodies should grow and work.

Now, sometimes our DNA can get a little wonky and form weird shapes. One of those shapes is called a polypurine reverse-hoogsteen hairpin.

Basically, this means that certain parts of the DNA strand (the purine bases) bunch together and form a loop, with other parts of the strand (the sugar-phosphate backbone) coming out of the loop. The "reverse-hoogsteen" part just refers to the orientation of the strands involved in the loop.

Scientists have found that these hairpins can form when the DNA is exposed to certain drugs or chemicals. They can also form naturally in certain parts of our DNA that are prone to mutations.

This might all sound a little confusing, but basically it just means that sometimes our DNA can twist and turn in unexpected ways, and scientists are still trying to understand how and why that happens.