ELI5: Explain Like I'm 5

Resiquimod

Resiquimod is like a superhero who helps your body fight bad guys called viruses and cancer cells. But, just like a superhero, he can be a little rough at first. When you first put on a medicine that has resiquimod in it, you might feel a little itchy or like you have a sunburn. This is because resiquimod is waking up your immune system so it can start fighting harder. Your immune system is like a team of tiny soldiers that protect your body from bad guys. When resiquimod wakes them up, they get stronger and can fight better. But don't worry, after a few days your skin should start feeling better and your body will be stronger and better able to fight off the bad guys.
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