ELI5: Explain Like I'm 5

Robinson annulation

Okay kiddo, let me explain the Robinson Annulation in a way that even a five-year-old could understand. So, do you know what a puzzle is? Yes? Great!

Imagine you have two puzzle pieces. One piece is called a ketone and the other is a cyclohexenone. Now, normally these two pieces wouldn't fit together like a puzzle. But we can make them fit by doing something special called a Robinson Annulation.

We're going to take the ketone piece and attach it to a special molecule called an alpha, beta-unsaturated carbonyl compound. That's just a fancy way of saying a molecule that has a double bond and a carbon-oxygen bond.

By doing this, we've made a new molecule that has a big ring and a little ring. Kind of like putting together a big puzzle with a little puzzle piece. This new molecule is called a bicyclic compound.

Why do we care about this? Well, bicyclic compounds can be used to make all sorts of things like medicines and chemicals for industry. The Robinson Annulation is a way to put together these compounds in a really efficient way. Isn't that cool?