ELI5: Explain Like I'm 5

SNP genotyping

Okay kiddo, so you know how everyone is different from each other, right? Well, there are tiny things called genetic variations in our DNA that make us unique. These variations are like spelling mistakes in a book, and they can affect how our body looks and works.

Scientists study these genetic variations to understand how they can lead to different diseases, help us predict how we may respond to certain drugs or treatments, and even help us learn about our ancestry. One of the ways scientists study these variations is by doing something called SNP genotyping.

Now, what's an SNP, you ask? Good question! SNPs, or single nucleotide polymorphisms (whew, that's a mouthful!), are just little changes in our DNA that happen when one single letter, or nucleotide, is different from what's usually there. Just like how changing one letter in a word can change its meaning, one SNP can sometimes change how our body works.

To find out what SNPs someone has, scientists do SNP genotyping. This is like a big science experiment where they take a tiny sample of someone's DNA (like getting a little bit of saliva or blood), and then look at all the SNPs in that sample. They use special machines to measure how many times each letter appears at each SNP location to figure out which versions of each SNP someone has.

Once they know all the SNPs someone has, scientists can compare them to other people's SNPs to see how similar or different they are. By doing this, they can learn more about how these genetic variations might affect a person's health, their family history, or even the whole human population.

Overall, SNP genotyping is a way for scientists to look at individual differences in our DNA and understand more about how each of us is unique. Pretty cool, huh?