ELI5: Explain Like I'm 5

Reduced muscle mass, strength and performance in space

In space, astronauts do not have the same gravity that people on Earth do. Gravity helps pull down on our muscles and helps them work properly. In space, without gravity, our muscles don't have to support our body so much, so they don't have to get as strong. That's why astronauts have less muscle mass, strength, and performance in space than they do on Earth.