ELI5: Explain Like I'm 5

Cahn–Ingold–Prelog priority rules

Imagine you have a bunch of different toys that you want to put in a line. But some of the toys are bigger or heavier than others, so you need to decide which one goes first, which one goes second, and so on.

Scientists have the same problem with molecules. They need to figure out which part of a molecule is the most important or the biggest, so they can talk about it in a clear way.

That's where the Cahn-Ingold-Prelog priority rules come in. They're like a set of instructions for deciding which part of a molecule is the most important.

Here's how it works:

1. Look at the different atoms in the molecule. Some atoms are bigger or have more stuff attached to them than others.

2. Decide which atom is the most important. This is usually based on how big the atom is or how much stuff is attached to it.

3. Once you've decided which atom is most important, assign it a priority. This means giving it a number. The most important atom gets the highest priority, which is usually 1.

4. Do the same thing for the other atoms in the molecule, giving each one a priority based on how important it is.

5. If two atoms have the same priority, look at the atoms attached to them. Whichever atom has the biggest or heaviest thing attached to it gets the higher priority.

6. Once you've assigned priorities to all the atoms, look at how the molecule is put together. If two atoms are connected by a single bond, that means they're tied for priority. But if they're connected by a double bond or a triple bond, that means they're not tied - one of them is more important.

7. Finally, arrange the atoms in order of priority. The atom with the highest priority goes first, followed by the one with the second-highest priority, and so on. This is called the "CIP sequence."

Scientists use the Cahn-Ingold-Prelog priority rules to describe molecules in a clear and consistent way. It helps them understand how molecules interact with each other and how they can be used in different reactions.