Okay kiddo, have you heard of something called marijuana or weed? It's a plant that some people use to feel better or have fun.
Marijuana has something inside it called cannabinoids. These are tiny things that can make your body feel different. They can help you relax or feel less pain.
When we say something is cannabinoidergic, it means it works with or affects these cannabinoids.
So a drug or a medicine that is cannabinoidergic might make you feel better by working with these tiny things inside marijuana.
Does that make sense, kiddo?