ELI5: Explain Like I'm 5

Capillary electrophoresis–mass spectrometry

Okay kiddo, so you know how there are different kinds of things in your body, like blood cells and proteins and other tiny things that we can't see with our eyes? Scientists want to study these tiny things to see how they work and how they can help us be healthier.

One way they can do this is by using a machine called a capillary electrophoresis-mass spectrometer (CE-MS for short). It's like a special magic wand that helps us see these tiny things!

First, they take a sample of a tiny thing they want to study (like protein). Then they put that sample into a tube with some special liquid. This liquid carries the tiny things through a tiny straw-like tube called a capillary.

As the tiny things move through the capillary, they start to separate from each other because they have different electric charges. The machine counts how many of each kind there are, like sorting out a bunch of different colored marbles.

Then, the separated tiny things get zapped by electricity, which turns them into little pieces called ions. These ions then move into a part of the machine called a mass spectrometer.

The mass spectrometer measures how heavy the ions are, because different tiny things have different weights. It's like sorting out the marbles by how heavy they are instead of what color they are.

Finally, the machine makes a graph that shows the different types of ions and how heavy they are. This graph helps the scientists understand what tiny things they are looking at and how they are different from each other.

So, in short, a capillary electrophoresis-mass spectrometer is a special machine that can sort out and measure tiny things in our bodies so that scientists can learn more about them and try to keep us healthy. Cool huh?