ELI5: Explain Like I'm 5

Classical complement pathway

Imagine your body as a castle that needs to be protected from invaders such as bacteria or viruses. Your body has special guards called complement proteins that help fight off these invaders.

The classical complement pathway is like a secret code that these guards use to identify intruders. First, a special group of "detective" proteins called antibodies attach themselves to the intruder. When enough antibodies have attached, it's like they've activated a secret alarm that tells the complement proteins to come and attack.

Once the complement proteins arrive, they start a chain reaction - like a row of dominos falling over. Each complement protein activates the next one in line until they form a complex that can literally poke a hole in the invading cell. This hole allows toxins to leak out and eventually kill the intruder.

So when your body is under attack, the classical complement pathway is like a secret code that tells your potential defenders exactly where the invaders are hiding. By activating this pathway, your body can quickly and efficiently eliminate the threat before it can do any harm.
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