Okay kiddo, so you know how sometimes when you eat too much candy, you start to feel sick? Well, that's because your body gets used to having a lot of sugar and it starts to react negatively to it.
Cross-sensitization is sort of like that, but with things that can make you sick in different ways. Let's say you have an allergy to peanuts - your body might react really strongly to peanuts and make you feel sick.
But here's the thing - your body might also react strongly to other things that are similar to peanuts, even if they aren't peanuts themselves. For example, if you have a peanut allergy, you might also have a reaction if you eat something that has been made in a factory that processes peanuts, even if the food itself doesn't have any peanuts in it.
This is called cross-sensitization because your body has become sensitive to one thing (peanuts) and now it's reacting strongly to something else (foods made in factories that process peanuts).
Sometimes cross-sensitization can happen with things that aren't even related to each other, like if you have an allergy to cats and then you start having a reaction to dust mites too. This happens because your body is kind of on high alert for anything that might cause it to react badly, so it starts overreacting to lots of different things.
Cross-sensitization can be tricky to deal with, but usually doctors can help you figure out what you're allergic to and how to avoid those things so you don't get sick.