ELI5: Explain Like I'm 5

Holocentric

Imagine a bicycle wheel with spokes going through the center of the wheel. Each of these spokes represents a chromosome in a cell. In humans, we have 23 pairs of chromosomes, which means we have 46 chromosomes in total.

Now imagine that instead of these chromosomes being attached at the center by the spokes, they are attached all along the length of the wheel. This is what we call a holocentric chromosome. It means that the centromere (the middle point of the chromosome) runs down the whole length of the chromosome instead of being concentrated in one spot.

This difference in chromosome structure affects how cells divide and organize their genetic material. Organsisms with holocentric chromosomes may have more flexibility in chromosome segregation during cell division, as well as the ability to undergo more complex chromosome rearrangements.

In summary, holocentric chromosomes are similar to a bicycle wheel with spokes, but instead of the spokes connecting at the center, the chromosomes are attached all along the length of the wheel. This unique structure can affect how cells divide and rearrange their genetic material.