ELI5: Explain Like I'm 5

Lipid bilayer phase behavior

Imagine you're building a tower with blocks. You take two blocks and place them on top of each other, then two more on top of those, and so on. You now have a tower with several layers, just like you have several layers of blocks. This tower represents what is called a lipid bilayer.

The lipid bilayer is made up of two layers of fat molecules, sort of like two stacks of pancakes put on top of each other. These fat molecules are called lipids, and they are sticky and don't mix well with water. Imagine trying to mix honey and water together – they don't mix!

Now, let's imagine that you're a little cookie monster (like from Sesame Street) and you're trying to eat a big plate of chocolate chip cookies. You decide to start with the top layer of cookies. You take a bite and then take a bite out of the next layer, and so on. Finally, you make your way down to the bottom layer.

The same thing can happen with the lipid bilayer. Sometimes the top layer of fat molecules is closer together, like when you stack your cookies really close together. Other times, the top layer is more spread out, like when you stack your cookies more loosely.

When the top layer is more closely packed, we call that a "solid" phase. When the top layer is more spread out, we call that a "liquid" phase.

So, to sum up, a lipid bilayer is made of two layers of fat molecules called lipids. These can be in a "solid" or "liquid" phase depending on how closely packed they are. Scientists study these different phases to understand how our cells work and how we can treat diseases.