Okay kiddo, you know how some things are attracted to water and some things aren't? Well, lipophilicity is all about how attracted something is to fats or oils instead of water.
You see, there are certain things in our bodies, like medicines or nutrients, that need to get into our cells to do their job. But our cells are made up of fat, which means they don't really like things that are attracted to water. That's where lipophilicity comes in - if something is lipophilic, it means it loves and is attracted to fats, which makes it easier for it to enter our cells and have the effect it's supposed to.
But not everything is lipophilic - some things really, really like water and don't care about fats at all. And sometimes, things can be both - like soap, which you use to wash your hands. Soap is lipophilic, so it sticks to the dirt and oils on your skin, but it's also hydrophilic, which means it washes away with water.
So, to sum it up - lipophilicity is all about how much something likes or is attracted to fats instead of water, and it can help things get into our cells to do their job.