ELI5: Explain Like I'm 5

Meiotic drive

Hey kiddo, have you ever heard of the term "meiotic drive"? It's kind of like a game that some special genes play, but don't worry, I'll explain it to you like you're five.

First thing you need to know is that we all have two copies of every gene, one from our mom and one from our dad. They are usually the same, but sometimes they can be a little different. Now imagine that there is a gene that has a special power, it can cheat and make sure that it's the one that gets passed on to the next generation more often than the other one. That's what meiotic drive genes do.

Here's how it works: when our cells divide to make eggs and sperm, they divide their DNA in half so that each egg or sperm only gets one copy of each gene. The game the meiotic drive gene plays is to cheat at this division stage, so that its copy of the gene goes into more eggs or sperm than its partner. It's like it's rigging the game.

Now, the really cool thing about meiotic drive is that it's a way for genes to spread throughout a population really quickly. If a meiotic drive gene is in a bunch of eggs or sperm, and those eggs or sperm go on to create babies, then those babies will also have the meiotic drive gene. And because it cheats, it will make sure that its copy of the gene goes into even more eggs or sperm in those babies, and so on and so on.

This kind of cheating can cause some problems though, especially if the meiotic drive gene causes problems for the individuals that carry it. Sometimes, individuals with a meiotic drive gene will have fewer offspring than those who don't carry the gene, because the gene is causing some kind of harm. But if the gene can cheat enough, it might still spread throughout the population.

Overall, meiotic drive is a pretty fascinating phenomenon in genetics. It's like a game that some genes play to try and make sure they get passed on more often than their partner, even if it means cheating a little bit.
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