ELI5: Explain Like I'm 5

Mitotic bookmarking

Mitotic bookmarking is a fancy way of explaining how cells remember certain things while they are dividing. When cells divide, they have to carefully copy all of their genetic information so that both new cells have the same set of instructions for how to grow and function. However, while this copying is happening, the cell's machinery is really busy and doesn't have time to read all of the genetic information.

This is where mitotic bookmarking comes in. Think of trying to read a book, but you don't have time to read every single word in it. Instead, you might put a bookmark in important sections that you want to come back to later. Similarly, when cells are dividing, they put bookmarks on certain parts of their DNA that are important for certain processes later on.

For example, if the cell needs to start making proteins that help it move in a certain way after it divides, it might put a bookmark on the section of DNA that contains the instructions for those proteins. This way, when the cell finishes dividing and is ready to start making those proteins, it can quickly find the right section of DNA thanks to the bookmark.

Mitotic bookmarking is an important mechanism that helps cells divide successfully and carry out important processes afterward. It's like leaving a reminder for ourselves to come back to something later, but at the cellular level!