Neonatal isoerythrolysis is an illness that can happen in newborn babies when their mother's and their father's blood type don't match. This can cause the baby to become very sick, and if not treated right away, it can even be fatal. When this happens, it's because the mother's and the father's blood have different antigens. Antigens are like tiny flags on each type of blood, and they can lead to the baby's body attacking itself if the flags don't match. As soon as this is discovered in a newborn, doctors can give the baby a special medicine that can protect it from the problem.