Nocebo is when someone has a bad reaction to something, even though it is not dangerous or harmful. It is the opposite of the placebo effect, which is when someone gets better after taking a pill or treatment even though the pill or treatment is not really doing anything. Nocebo is when someone feels worse after taking a pill or treatment even though the pill or treatment is not doing anything bad. It can be caused by a person thinking something bad will happen and then their mind makes it happen.