Off-label use means when a doctor tells you to take medicine for something that it was not originally made for. For example, if a doctor tells you to take a medicine for a headache even though it was only approved to treat allergies, that's off-label use. This can happen when a doctor thinks a medicine might help with a problem, even if the medicine hasn't been officially tested and approved for that problem. Off-label use can be safe, but it can also be risky because the medicine might not work or it could even be harmful. Doctors usually only prescribe off-label if they think it's the best option for your health.