ELI5: Explain Like I'm 5

Portal-visceral hypothesis

Okay kiddo, so you know how our body is made up of different organs like the heart, liver, and lungs?

Now, imagine if all these organs were connected by a bunch of strings like a spider web. These strings are called nerves and blood vessels. When we eat food, our stomach sends a message to our brain that we're full. This message travels through these strings to the brain.

The portal-visceral hypothesis is a theory that says that some diseases like liver disease start because of problems with these strings. Specifically, there's a string called the portal vein. This vein connects the stomach and intestines to the liver. When we eat, the nutrients from the food go through this vein to the liver.

If there's a problem with the portal vein, it can damage the liver and cause liver disease. It's like if one of the strings in our spider web is broken or blocked.

Scientists are still studying this hypothesis to understand how it affects our health. So, it's important to take good care of our bodies by eating healthy foods and getting enough exercise, so we don't put too much strain on these strings!