ELI5: Explain Like I'm 5

Protein structure prediction

Protein structure prediction is like trying to build a castle using only a picture. Now, a castle is made up of different parts like walls, towers, and doors. Similarly, a protein is made up of smaller units called amino acids, just like the building blocks used to build a castle.

But here's the tricky part - we don't know exactly how these amino acids fit together to create a protein shape. It's like trying to build a castle without knowing the exact location of each brick.

To figure out the structure of a protein, scientists use their knowledge of how amino acids fit together and try to predict the final shape of the protein. They do this by using computers to simulate different possible structures and calculating which one is most likely to be correct. Just like when we play pretend, we might imagine different ways to build a castle and choose the best one based on our imagination.

Once scientists have predicted the protein structure, they can use it to understand how the protein works and how it might interact with other molecules in the body. This can be very helpful in developing new drugs or treatments for diseases.

In summary, predicting protein structure is like trying to build a castle using a picture without knowing the exact location of each brick. Scientists use computers and their imagination to predict the structure and use it to understand how the protein works in the body.