ELI5: Explain Like I'm 5

Reverse vaccinology

Okay kiddo, do you know what a vaccine is? It's a special medicine that helps your body fight off bad germs that can make you sick. But sometimes scientists want to make a vaccine for a new sickness that they don't know very much about. That's where reverse vaccinology comes in.

Reverse vaccinology is like a puzzle game for scientists. They use it to figure out how a new sickness works and what parts of it can make people sick. Here's how they do it:

First, they take a tiny piece of the sickness and study it very closely. This piece is called a protein. They look at the protein like it's a picture and try to see all the little details.

Next, they use a computer to draw a map of the protein. The map shows them where all the pieces of the protein are and how they fit together.

Then, they try to find the pieces of the protein that could make people sick if they got inside their body. They circle those pieces on the map.

Finally, they make a vaccine that teaches your body how to fight against those bad pieces of the protein. When your body knows how to fight them, it can keep you from getting sick!

So that's what reverse vaccinology is all about, buddy. It's like a puzzle game that helps scientists make new vaccines to keep you healthy.