SNV calling from NGS data
Ok kiddo, so imagine you have a bunch of puzzle pieces that make up a picture of your dog. But some of these pieces might be a little different or "mutated".
When scientists study your dog's DNA using something called Next-Generation Sequencing (or NGS for short), they get a big jumbled mess of data that needs to be pieced together just like a puzzle.
SNV stands for Single Nucleotide Variant, which basically means that some of these puzzle pieces (or nucleotides) might be a little different or changed in some way.
So snv calling is when scientists try to figure out which of these puzzle pieces are different and how they are different. They use fancy computer programs to compare your dog's DNA sequence with a "reference" sequence to detect these changes.
Think of it like trying to find the different colored puzzle pieces in a bunch of jumbled up puzzle pieces of your dog. Scientists use this process to learn more about the genetics of animals or people and even help find treatments for diseases.
When scientists study your dog's DNA using something called Next-Generation Sequencing (or NGS for short), they get a big jumbled mess of data that needs to be pieced together just like a puzzle.
SNV stands for Single Nucleotide Variant, which basically means that some of these puzzle pieces (or nucleotides) might be a little different or changed in some way.
So snv calling is when scientists try to figure out which of these puzzle pieces are different and how they are different. They use fancy computer programs to compare your dog's DNA sequence with a "reference" sequence to detect these changes.
Think of it like trying to find the different colored puzzle pieces in a bunch of jumbled up puzzle pieces of your dog. Scientists use this process to learn more about the genetics of animals or people and even help find treatments for diseases.