ELI5: Explain Like I'm 5

Secretory pathway

Okay kiddo, so let's start with a big word: secretory pathway. This is how our cells, and lots of other living things, make and release things outside of themselves.

Now, all of our cells have tiny factories inside of them called organelles. Two of these organelles are called the endoplasmic reticulum (ER) and the Golgi apparatus. They work together to make, package, and transport things - like hormones, enzymes, and new membranes for cells.

When our cells make something that needs to be secreted, it starts in the ER. The ER produces a little bubble called a vesicle that contains the thing, like a hormone for example. The vesicle then buds off from the ER and moves over to the Golgi.

Now the Golgi is really important. It's like a post office for cells because it sorts and labels things. When the vesicle arrives, the Golgi looks at the label on the vesicle and sends it to the right "address" - basically, where it needs to go. The Golgi also puts final touches on the vesicle's contents, like adding a sugar coating called a glycan.

Finally, the vesicle is ready to leave the cell and be released into the outside world. It moves to the cell's surface and fuses with the cell membrane. The contents of the vesicle spill out and are free to go wherever they need to go in the body.

So, that's the secretory pathway. It's how our cells make things and send them off to do their job outside of the cell. Pretty cool, huh?