ELI5: Explain Like I'm 5

Selective estrogen receptor modulator

Imagine your body has locks and keys – locks are the receptors, and keys are the hormones that fit into them. Estrogen, a hormone that helps us develop and maintain our female characteristics, has a key that fits into specific locks (receptors) throughout our body. Some of these locks are found in the bones, brain, and breasts.

Now, sometimes there can be too much estrogen in our bodies, which can lead to health problems like breast cancer. In other cases, a woman may not have enough estrogen, which can cause problems like osteoporosis (weak bones). This is why doctors have developed something called a selective estrogen receptor modulator, or SERM for short.

A SERM is like a special key that can fit into the locks where estrogen fits, but it can also do other things. Depending on where in the body the lock is, the SERM can work differently. For example, if the SERM fits into a lock in the breast, it can block estrogen from fitting in and causing breast cancer. But, if the SERM fits into a lock in the bones, it can actually help the bones absorb more calcium, keeping them strong and healthy.

So, essentially, a SERM is a special key that can fit into different locks throughout the body and do different things, depending on where it is needed. By using a SERM, doctors can help balance estrogen levels in the body and prevent or treat certain health problems.