ELI5: Explain Like I'm 5

Short linear motif

Okay, kiddo! A short linear motif (SLiM) is like a secret code that tells the cells in our bodies what to do.

Each cell has many proteins inside it that help it do its job. Think of proteins like tiny machines that work together to keep the cell running.

Sometimes, these proteins need to talk to each other to know what to do. And that's where SLiMs come in.

A SLiM is a small part of a protein that acts like a signal. It tells other proteins what to do. It's like a secret handshake between proteins.

For example, a protein might have a SLiM that says "hey, attach to this other protein." Or it might say "go to this part of the cell and do your job there."

Scientists study SLiMs to learn more about how proteins work together inside our cells. They can use this knowledge to develop new medicines or treatments for diseases.

So there you have it, a short linear motif is like a tiny secret code that helps proteins talk to each other and do their jobs in our cells.