ELI5: Explain Like I'm 5

Tajima's D

Okay, imagine you have a bunch of toys in a box. Some of these toys are red, and some are blue. Now, let's say you want to know if there are more red toys or more blue toys in the box.

Tajima's D is like a way to figure out if there are more of one color than the other. It looks at how many different "types" or "versions" of a certain gene there are in a population.

So, let's say we're looking at a population of birds. We want to know if there are more birds with a certain type of beak, or if there are an equal amount of birds with that beak and a different type of beak. Tajima's D can help us figure that out.

The formula for Tajima's D looks at two things: the number of differences in the DNA of the birds we're looking at, and the amount of variation we would expect to see based on how big the population is.

If there are more differences in the DNA than we would expect, that means there might be something going on that's causing some birds to have a certain DNA sequence that's different from others (like maybe birds with that different sequence are better at getting food or surviving). If there are fewer differences than we'd expect, that might mean that most birds have the same DNA because they all descend from a common ancestor.

So, Tajima's D is like a way to tell if there's something weird or interesting going on with the DNA of a certain population of animals or plants.