ELI5: Explain Like I'm 5

Transmission electron microscopy

Okay, so imagine you have a really special microscope. But instead of using regular light to see things like a regular microscope, it uses tiny things called electrons. These electrons are super small particles that are used kind of like a flashlight to illuminate and make pictures of really small things that are way too small to see with just your eyes.

Now with this special microscope, we can see things that are way smaller than what you can see with a regular microscope. We can even see things that are a billionth of a meter in size! That's super tiny!

Now, there are different types of electron microscopes, but we're going to talk about one called the "transmission electron microscope" (TEM for short).

So, what makes the TEM special is that it can take pictures of things that are inside of things. You know how when you look at a person, you can't really see all their bones and stuff inside? But if you had a camera that could take a picture through their skin, you could see everything inside? That's kind of like what a TEM can do, but instead of taking pictures of bones, it takes pictures of really tiny things like cells and atoms.

It does this by shooting a beam of electrons through a super thin slice of the thing we want to see. The electrons go through the slice and then hit a screen that captures the image. Think of it like a game of darts, but instead of hitting a dartboard, the electrons hit the screen and make a picture.

Now, because the thing we want to see is super tiny, we have to make the slice really thin too so that the electrons can pass through it. This is kind of like trying to slice a piece of bread super thin so it's easier to eat. So, scientists use a really special machine called an Electron Microscope (EM) to slice the things we want to see really thin.

Once we have the super thin slice, we put it into the TEM, shoot electrons through it, and ta-da! We can see the tiny stuff inside! It's like a magic window that let us look at really small things.

Scientists use TEMs to study things like viruses, cells, and even individual molecules. This helps them learn more about how things work and can even help them develop new medicines and technologies to help people.