ELI5: Explain Like I'm 5

Active chromatin sequence

Active chromatin sequence is like a jigsaw puzzle. It's made up of many little pieces. These pieces, called chromatin, are like the pieces of a jigsaw puzzle that fit together to make a picture. Instead of a picture, the chromatin pieces help to build different parts of the cell. The active chromatin sequence is like the pieces that are used more often to build those parts of the cell. An active chromatin sequence gives the cell the ability to do a certain job, like make energy or defend against bad things. It's like having a special puzzle piece that helps the cell work better.
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