An adjustment handle is like a little lever or knob that you can turn or move to change something. It's kind of like the steering wheel on a car - when you turn it, the car goes in a different direction.
But instead of making a car go a different way, an adjustment handle might change the height of your chair, the brightness of your computer screen, or the temperature in your house.
So basically, whenever you need to make something different or better, you can use an adjustment handle to help you do it!