ELI5: Explain Like I'm 5

Aromatase deficiency

Okay kiddo, so let's talk about hormones. You know how some people have different body parts, right? Like boys have pee-pees and girls have hoo-hoos? Well, those body parts make hormones - which are like tiny messages that tell your body what to do.

One hormone that some people make is called testosterone. That's usually what boys make, but girls have it too - just not as much. Testosterone helps make people muscles bigger, hairier and stronger.

Another hormone is called estrogen. That's usually what girls make, but boys have it too - just not as much. Estrogen helps make people boobs grow and hips wider.

But sometimes, someone's body doesn't make enough estrogen. That's called 'aromatase deficiency'. Aromatase is an enzyme or a tool that helps make estrogen. Without enough aromatase, the body can't make enough estrogen. That can cause problems for girls, like not getting their period, not growing like they should, and not having big enough boobs.

But it can also cause problems for boys too! Remember how testosterone makes muscles bigger and hairier? If there's not enough estrogen to balance it out, the boy's muscles might grow too much - and they might not like that! Plus, without enough estrogen, boys might not grow up to be as tall as they should be.

So sometimes, doctors might give people with aromatase deficiency some extra estrogen. That can help balance out their hormones and make sure they grow up nice and healthy!