ELI5: Explain Like I'm 5

Estrogen insensitivity syndrome

Hi there,
So, you know how boys and girls are different, right? One of the things that makes boys different from girls is that boys have something called testosterone that helps them develop certain things, like muscles and deep voices. Girls have a different hormone called estrogen that helps them develop in other ways, like growing breasts and starting their periods.

Sometimes, though, things can go a little bit differently. When a girl is born, she may not be able to respond to the estrogen hormone like most other girls can. This means that even though she has estrogen in her body, it doesn't work the way it's supposed to. This is called "estrogen insensitivity syndrome."

When a girl has estrogen insensitivity syndrome, she might look like a typical girl on the outside, but inside her body, things may be different. Because she can't respond to estrogen, her body might not develop as expected. For example, she might not grow breasts or have a period, even when she gets older. She might also have other health issues, like trouble with her bones or with her fertility (which means she might not be able to have a baby when she's older).

But don't worry, there are treatments that can help girls with estrogen insensitivity syndrome. Doctors might give them hormones (like testosterone or some other kind of estrogen) to help their bodies develop in the right way. And even though things might be a bit different for girls with estrogen insensitivity syndrome, they're still able to have happy and healthy lives, just like anyone else!